A: Yes it has direct diuretic property! Digoxin increases diuresis by at least 4 mechanisms
- Direct vasodilation
- Increased CO improves renal hemodynamics
- Inhibition of tubular reabsorption of sodium, of renal Na+ -K+-ATPase, and of concentrating and diluting ability
- Increased secretion of atrial natriuretic peptide
Reference:
1. Rahimtoola SH, Tak T. The use of digitalis in heart failure. Curr Probl Cardiol. 1996; 21: 781–756
