Thursday, February 17, 2011

Is anti-platelet also protective for Acute Lung Injury (ALI)?

In one of the recent study published recently in 'Chest', it showed that people with prehospitalization Antiplatelet Therapy have a reduced incidence of ALI/ARDS!

Platelet activation is a key component of ALI pathophysiology so investigators examined the association of prehospitalization antiplatelet therapy with development of ALI in critically ill patients. A total of 161 patients were evaluated. Seventy-nine (49%) were receiving antiplatelet therapy at hospital admission; 33 (21%) developed ALI/ARDS. Antiplatelet therapy was associated with a reduced incidence of ALI/ARDS (12.7% vs 28.0%; OR, 0.37; 95% CI, 0.16-0.84; P = .02). This association remained significant after adjusting for confounding variables.



Prehospitalization Antiplatelet Therapy Is Associated With a Reduced Incidence of Acute Lung Injury, A Population-Based Cohort Study - CHEST February 2011 vol. 139 no. 2 289-295 (

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